The northernmost section of the E1 in Italy begins in Porto Ceresio on Lake Lugano opposite Switzerland. The "Parco Regionale del Campo dei Fiori" is traversed in initially still mountainous terrain before the E1 reaches Lago di Varese and leaves the Alps behind. From Sesto Calende, the E1 follows the Ticino River through the Po Valley west of Milan.
Shortly before Pavia, the E1 leaves the Ticino in a south-westerly direction and leads to the Po and Piedmont.
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